Lapi Group at University of Alabama at Birmingham

Burkemper JL, Aweda,TA, Rosenberg AJ, Lunderberg DL, Peaslee GF, Lapi S.E. (2017) Radiosynthesis and biological distribution of [18F]-labeled perfluorinated alkyl substances. Environmental Science and Technology Letters, DOI:10.1021/acs.estlett.7b00042
Wooten AL, Aweda TA, Lewis BC, Gross RB, Lapi S.E.(2017) Biodistribution and PET Imaging of pharmacokinetics of manganese in mice using Manganese-52. PLoS One, 2017 Mar; 12(3):e0174351.doi:10.137
Queern, SL, Aweda TA, Massicano AV, Clanton, NA, El Sayed, R, Sader, JA, Lapi, S.E. (2017) Production of Zr-89 using sputtered yttrium coin targets. Nuclear Medicine and Biology, 2017 Mar 23;50:11-16. doi: 10.1016.
Marquez-Nostra BV, Lee S, Laforest R, Vitale L, Nie X, Hyrc K, Keler T, Hawthorne T, Hoog J, Li S, Dehdashti F, Ma CX, Lapi SE. Preclinical PET imaging of glycoprotein non-metastatic melanoma B in triple negative breast cancer: feasibility of an antibody-based companion diagnostic agent. Oncotarget. 2017 Nov 1;8(61):104303-104314.doi: 10.18632.
Radka, C. D., Radford, L. L., Massicano, A. V., DeLucas, L. J., Lapi, S. E., Aller, S. G. (2018) Essential Metal Uptake in Gram-negative Bacteria: X-ray Fluorescence, Radioisotopes, and Cell Fractionation. J. Vis. Exp. (132), e57169, doi:10.3791/57169 (2018).
Massicano, A.V., Marquez-Nostra, B.V., Lapi, S.E. (2018) Targeting HER2 in Nuclear Medicine for Imaging and Therapy. Molecular Imaging. 2018 January. PMCID: PMC5784567.
Dehdashti F, Wu N, Bose R, Naughton MJ, Ma CX, Marquez-Nostra BV, Diebolder P, Mpoy C, Rogers BE, Lapi S.E., Laforest R, Siegel BA. (2018) Evaluation of [89Zr]trastuzumab-PET/CT in differentiating HER2-positive from HER2-negative breast cancer. Breast Cancer Research and Treatment. 2018 Feb 13. doi: 10.1007/s10549-018-4696-z.
Larson-Casey JL, Gu L, Jackson PL, Briles DE, Hale JY, Blalock JE, Wells JM, Deshane JS, Wang Y, Davis D, Antony VB, Massicano AVF, Lapi S.E., Carter AB. (2018) Macrophage Rac2 Is Required to Reduce the Severity of Cigarette Smoke-induced Pneumonia. American Journal of Respiratory and Critical Care Medicine. 2018 Jun 13. doi: 10.1164/rccm.201712-2388OC.
Schnoover, K.E., Queern, S.L., Lapi, S.E., Roberts, R. C., Impaired copper transport in schizophrenia results in a copper-deficient brain state: a New side to the dysbindin story. The World Journal of Biological Psychiatry. 2018 Sep 19. DOI: 10.1080/15622975.2018.1523562
Chaple, I.F., Lapi, S.E., Production and use of first row transition metal PET radionuclides, 43,44Sc, 52Mn, and 45Ti. Journal of Nuclear Medicine. 2018 Nov 1. vol. 59 no. 11 1655-1659
Shusterman JA, Scielzo ND, Thomas KJ, Norman EB, Lapi SE, Loveless CS, Peters NJ, Robertson JD, Shaughnessy DA, Tonchev AP. The surprisingly large neutron capture cross-section of 88Zr. Nature. 2019 Jan;565(7739):328-330. doi: 10.1038/s41586-018-0838-z. Epub 2019 Jan 7.
Massicano AVF, Lee S, Crenshaw BK, Aweda TA, El Sayed R, Super I, Bose R, Marquez-Nostra BV, Lapi SE. Imaging of HER2 with [89Zr]pertuzumab in Response to T-DM1 Therapy. Cancer Biotherapy & Radiopharmaceuticals. 24 Jan 2019. doi: 10.1089/cbr.2018.2654.
Marston JC, Kennedy GD, Lapi SE, Hartman YE, Richardson MT, Modi HM, Warram JM. Panitumumab-IRDye800CW for Fluorescence-Guided Surgical Resection of Colorectal Cancer. Journal of Surgical Research. 2019 Feb 21;239:44-51. doi: 10.1016/j.jss.2019.01.065.
El Sayed R, Massicano AVF, Queern SL, Loveless CS, Lapi SE. Manganese-52 production cross-section measurements via irradiation of natural chromium targets up to 20 MeV. Applied Radiation and Isotopes. 2019 Mar 1;147:165-170. doi: 10.1016/j.
Benedetto R, Massicano AVF, Crenshaw BK, Oliveira R, Reis RM, Araújo EB, Lapi SE. 89Zr-DFO-Cetuximab as a Molecular Imaging Agent to Identify Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma. Cancer Biotherapy & Radiopharmaceuticals. 2019 Mar 13. doi: 10.1089/cbr.2018.2616.
Crawford CL, Dalecki AG, Narmore WT, Hoff J, Hargett AA, Renfrow MB, Zhang M, Kalubowilage M, Bossmann SH, Queern SL, Lapi SE, Hunter RN, Bao D, Augelli-Szafran CE, Kutsch O, Wolschendorf F. Pyrazolopyrimidinones, a novel class of copper-dependent bactericidal antibiotics against multi-drug resistant S. aureus. Metallomics. 2019 Mar 11. doi: 10.1039/c8mt00316e.
Carter, L.M., Kesner, A.L., Pratt, E..C, Sanders, V.A., Massicano, A.V.F. Cutler, C.S. Lapi, S.E., Lewis, J.S. The Impact of Positron Range on PET Resolution, Evaluated with Phantoms and PHITS Monte Carlo Simulations for Conventional and Non-conventional Radionuclides. Molecular Imaging and Biology. 2019 Apr 18. doi: 10.1007/s11307-019-01337-2. PubMed PMID: 31001765.
Lapi, S.E., Engle, J.W. Radiochlorine: an underutilized halogen tool Radiochimica Acta May 2019 DOI: https://doi.org/10.1515/ract-2019-0015
Loveless C.S., Radford L.L., Ferran S.J., Queern S.L., Shepherd M.R., Lapi S.E.. Photonuclear production, chemistry, and in vitro evaluation of the theranostic radionuclide 47Sc. EJNMMI Res. 2019 May 16;9(1):42. doi: 10.1186/s13550-019-0515-8. PubMed PMID: 31098710
Guenter, R.E., Aweda, T., Carmona Matos, D.M., Whitt, J., Chang, A.W., Cheng, E.Y., Liu, X.M., Chen, H., Lapi, S.E., Jaskula-Sztul, R. Pulmonary Carcinoid Surface Receptor Modulation Using Histone Deacetylase Inhibitors. Cancers (Basel). 2019 Jun 3;11(6). doi: 10.3390/cancers11060767. PubMed PMID: 31163616.
Mikolajczak R., van der Meulen N.P., Lapi S.E., Radiometals for imaging and theranostics, current production and future perspectives. J Labelled Comp Radiopharm. 2019 May 28;. doi: 10.1002/jlcr.3770. [Epub ahead of print] PubMed PMID: 31137083.
Kasten BB, Udayakumar N, Leavenworth JW, Wu AM, Lapi SE, McConathy JE, Sorace AG, Bag AK, Markert JM, Warram JM. Current and Future Imaging Methods for Evaluating Response to Immunotherapy in Neuro-Oncology. Theranostics. 2019;9(17):5085-5104. doi: 10.7150/thno.34415. eCollection 2019. Review. PubMed PMID: 31410203; PubMed Central PMCID: PMC6691392.
Herring B, Whitt J, Aweda T, Ou J, Guenter R, Lapi S, Berry J, Chen H, Liu X, Rose JB, Jaskula-Sztul R. A growth model of neuroendocrine tumor surrogates and the efficacy of a novel somatostatin-receptor-guided antibody-drug conjugate: Perspectives on clinical response? Surgery. 2019 Sep 19. pii: S0039-6060(19)30563-X. doi: 10.1016/j.surg.2019.04.073.
Guenter R, Aweda T, Carmona Matos DM, Jang S, Whitt J, Cheng YQ, Liu XM, Chen H, Lapi SE, Jaskula-Sztul R. Overexpression of somatostatin receptor type 2 in neuroendocrine tumors for improved Ga68-DOTATATE imaging and treatment. Surgery. 2019 Oct 16;. doi: 10.1016/j.surg.2019.05.092. PubMed PMID: 31629542.
Ellison PA, Olson AP, Barnhart TE, Hoffman SLV, Reilly SW, Makvandi M, Bartels JL, Murali D, DeJesus OT, Lapi SE, Bednarz B, Nickles RJ, Mach RH, Engle JW. Improved production of 76Br, 77Br and 80mBr via CoSe cyclotron targets and vertical dry distillation. Nucl Med Biol. 2019 Sep 5;. doi: 10.1016/j.nucmedbio.2019.09.001. PubMed PMID: 31575457.
Radford LL, Fernandez S, Beacham R, El Sayed R, Farkas R, Benešová M, Müller C, Lapi SE. New 55Co-labeled Albumin-Binding Folate Derivatives as Potential PET Agents for Folate Receptor Imaging. Pharmaceuticals (Basel). 2019 Nov 8;12(4). doi: 10.3390/ph12040166. PubMed PMID: 31717279.

Lapi Research Group at the University of Alabama at Birmingham

Recent publications (From a total of 87)

Burkemper JL, Aweda,TA, Rosenberg AJ, Lunderberg DL, Peaslee GF, Lapi S.E. (2017) Radiosynthesis and biological distribution of [18F]-labeled perfluorinated alkyl substances. Environmental Science and Technology Letters, DOI:10.1021/acs.estlett.7b00042

Wooten AL, Aweda TA, Lewis BC, Gross RB, Lapi S.E.(2017) Biodistribution and PET Imaging of pharmacokinetics of manganese in mice using Manganese-52. PLoS One, 2017 Mar; 12(3):e0174351.doi:10.137

Queern, SL, Aweda TA, Massicano AV, Clanton, NA, El Sayed, R, Sader, JA, Lapi, S.E. (2017) Production of Zr-89 using sputtered yttrium coin targets. Nuclear Medicine and Biology, 2017 Mar 23;50:11-16. doi: 10.1016.

Radka, C. D., Radford, L. L., Massicano, A. V., DeLucas, L. J., Lapi, S. E., Aller, S. G. (2018) Essential Metal Uptake in Gram-negative Bacteria: X-ray Fluorescence, Radioisotopes, and Cell Fractionation. J. Vis. Exp. (132), e57169, doi:10.3791/57169 (2018).

Massicano, A.V., Marquez-Nostra, B.V., Lapi, S.E. (2018) Targeting HER2 in Nuclear Medicine for Imaging and Therapy. Molecular Imaging. 2018 January. PMCID: PMC5784567.

Schnoover, K.E., Queern, S.L., Lapi, S.E., Roberts, R. C., Impaired copper transport in schizophrenia results in a copper-deficient brain state: a New side to the dysbindin story. The World Journal of Biological Psychiatry. 2018 Sep 19. DOI: 10.1080/15622975.2018.1523562

Chaple, I.F., Lapi, S.E., Production and use of first row transition metal PET radionuclides, 43,44Sc, 52Mn, and 45Ti. Journal of Nuclear Medicine. 2018 Nov 1. vol. 59 no. 11 1655-1659

Shusterman JA, Scielzo ND, Thomas KJ, Norman EB, Lapi SE, Loveless CS, Peters NJ, Robertson JD, Shaughnessy DA, Tonchev AP. The surprisingly large neutron capture cross-section of 88Zr. Nature. 2019 Jan;565(7739):328-330. doi: 10.1038/s41586-018-0838-z. Epub 2019 Jan 7.

Massicano AVF, Lee S, Crenshaw BK, Aweda TA, El Sayed R, Super I, Bose R, Marquez-Nostra BV, Lapi SE. Imaging of HER2 with [89Zr]pertuzumab in Response to T-DM1 Therapy. Cancer Biotherapy & Radiopharmaceuticals. 24 Jan 2019. doi: 10.1089/cbr.2018.2654.

Marston JC, Kennedy GD, Lapi SE, Hartman YE, Richardson MT, Modi HM, Warram JM. Panitumumab-IRDye800CW for Fluorescence-Guided Surgical Resection of Colorectal Cancer. Journal of Surgical Research. 2019 Feb 21;239:44-51. doi: 10.1016/j.jss.2019.01.065.

El Sayed R, Massicano AVF, Queern SL, Loveless CS, Lapi SE. Manganese-52 production cross-section measurements via irradiation of natural chromium targets up to 20 MeV. Applied Radiation and Isotopes. 2019 Mar 1;147:165-170. doi: 10.1016/j.

Benedetto R, Massicano AVF, Crenshaw BK, Oliveira R, Reis RM, Araújo EB, Lapi SE. 89Zr-DFO-Cetuximab as a Molecular Imaging Agent to Identify Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma. Cancer Biotherapy & Radiopharmaceuticals. 2019 Mar 13. doi: 10.1089/cbr.2018.2616.

Lapi, S.E., Engle, J.W. Radiochlorine: an underutilized halogen tool Radiochimica Acta May 2019 DOI: https://doi.org/10.1515/ract-2019-0015

Loveless C.S., Radford L.L., Ferran S.J., Queern S.L., Shepherd M.R., Lapi S.E.. Photonuclear production, chemistry, and in vitro evaluation of the theranostic radionuclide 47Sc. EJNMMI Res. 2019 May 16;9(1):42. doi: 10.1186/s13550-019-0515-8. PubMed PMID: 31098710

Mikolajczak R., van der Meulen N.P., Lapi S.E., Radiometals for imaging and theranostics, current production and future perspectives. J Labelled Comp Radiopharm. 2019 May 28;. doi: 10.1002/jlcr.3770. [Epub ahead of print] PubMed PMID: 31137083.

Radford LL, Fernandez S, Beacham R, El Sayed R, Farkas R, Benešová M, Müller C, Lapi SE. New 55Co-labeled Albumin-Binding Folate Derivatives as Potential PET Agents for Folate Receptor Imaging. Pharmaceuticals (Basel). 2019 Nov 8;12(4). doi: 10.3390/ph12040166. PubMed PMID: 31717279.

Lapi Research Group at the University of Alabama at Birmingham

Recent publications (From a total of 87)

Burkemper JL, Aweda,TA, Rosenberg AJ, Lunderberg DL, Peaslee GF, Lapi S.E. (2017) Radiosynthesis and biological distribution of [18F]-labeled perfluorinated alkyl substances. Environmental Science and Technology Letters, DOI:10.1021/acs.estlett.7b00042

Wooten AL, Aweda TA, Lewis BC, Gross RB, Lapi S.E.(2017) Biodistribution and PET Imaging of pharmacokinetics of manganese in mice using Manganese-52. PLoS One, 2017 Mar; 12(3):e0174351.doi:10.137

Queern, SL, Aweda TA, Massicano AV, Clanton, NA, El Sayed, R, Sader, JA, Lapi, S.E. (2017) Production of Zr-89 using sputtered yttrium coin targets. Nuclear Medicine and Biology, 2017 Mar 23;50:11-16. doi: 10.1016.

Radka, C. D., Radford, L. L., Massicano, A. V., DeLucas, L. J., Lapi, S. E., Aller, S. G. (2018) Essential Metal Uptake in Gram-negative Bacteria: X-ray Fluorescence, Radioisotopes, and Cell Fractionation. J. Vis. Exp. (132), e57169, doi:10.3791/57169 (2018).

Massicano, A.V., Marquez-Nostra, B.V., Lapi, S.E. (2018) Targeting HER2 in Nuclear Medicine for Imaging and Therapy. Molecular Imaging. 2018 January. PMCID: PMC5784567.

Schnoover, K.E., Queern, S.L., Lapi, S.E., Roberts, R. C., Impaired copper transport in schizophrenia results in a copper-deficient brain state: a New side to the dysbindin story. The World Journal of Biological Psychiatry. 2018 Sep 19. DOI: 10.1080/15622975.2018.1523562

Chaple, I.F., Lapi, S.E., Production and use of first row transition metal PET radionuclides, 43,44Sc, 52Mn, and 45Ti. Journal of Nuclear Medicine. 2018 Nov 1. vol. 59 no. 11 1655-1659

Shusterman JA, Scielzo ND, Thomas KJ, Norman EB, Lapi SE, Loveless CS, Peters NJ, Robertson JD, Shaughnessy DA, Tonchev AP. The surprisingly large neutron capture cross-section of 88Zr. Nature. 2019 Jan;565(7739):328-330. doi: 10.1038/s41586-018-0838-z. Epub 2019 Jan 7.

Massicano AVF, Lee S, Crenshaw BK, Aweda TA, El Sayed R, Super I, Bose R, Marquez-Nostra BV, Lapi SE. Imaging of HER2 with [89Zr]pertuzumab in Response to T-DM1 Therapy. Cancer Biotherapy & Radiopharmaceuticals. 24 Jan 2019. doi: 10.1089/cbr.2018.2654.

Marston JC, Kennedy GD, Lapi SE, Hartman YE, Richardson MT, Modi HM, Warram JM. Panitumumab-IRDye800CW for Fluorescence-Guided Surgical Resection of Colorectal Cancer. Journal of Surgical Research. 2019 Feb 21;239:44-51. doi: 10.1016/j.jss.2019.01.065.

El Sayed R, Massicano AVF, Queern SL, Loveless CS, Lapi SE. Manganese-52 production cross-section measurements via irradiation of natural chromium targets up to 20 MeV. Applied Radiation and Isotopes. 2019 Mar 1;147:165-170. doi: 10.1016/j.

Benedetto R, Massicano AVF, Crenshaw BK, Oliveira R, Reis RM, Araújo EB, Lapi SE. 89Zr-DFO-Cetuximab as a Molecular Imaging Agent to Identify Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma. Cancer Biotherapy & Radiopharmaceuticals. 2019 Mar 13. doi: 10.1089/cbr.2018.2616.

Lapi, S.E., Engle, J.W. Radiochlorine: an underutilized halogen tool Radiochimica Acta May 2019 DOI: https://doi.org/10.1515/ract-2019-0015

Loveless C.S., Radford L.L., Ferran S.J., Queern S.L., Shepherd M.R., Lapi S.E.. Photonuclear production, chemistry, and in vitro evaluation of the theranostic radionuclide 47Sc. EJNMMI Res. 2019 May 16;9(1):42. doi: 10.1186/s13550-019-0515-8. PubMed PMID: 31098710

Mikolajczak R., van der Meulen N.P., Lapi S.E., Radiometals for imaging and theranostics, current production and future perspectives. J Labelled Comp Radiopharm. 2019 May 28;. doi: 10.1002/jlcr.3770. [Epub ahead of print] PubMed PMID: 31137083.

Radford LL, Fernandez S, Beacham R, El Sayed R, Farkas R, Benešová M, Müller C, Lapi SE. New 55Co-labeled Albumin-Binding Folate Derivatives as Potential PET Agents for Folate Receptor Imaging. Pharmaceuticals (Basel). 2019 Nov 8;12(4). doi: 10.3390/ph12040166. PubMed PMID: 31717279.

El Sayed R, Massicano AVF, Queern SL, Loveless CS, Lapi SE. Manganese-52 production cross-section measurements via irradiation of natural chromium targets up to 20 MeV. Applied Radiation and Isotopes. 2019 Mar 1;147:165-170. doi: 10.1016/j.